Author, date and country | Patient group | Study type (level of evidence) | Outcomes | Key results | Study Weaknesses |
---|---|---|---|---|---|
Gorman DF, 1987, England | 5768 head injuries in all age groups 6685 head injuries in all age groups | Retrospective case note review Prospective patient study | Presence of skull fracture | More common in vomiting children (p<0.005). 7% of all patients vomited. 25.7% of patients with skull fracture vomited | Not specific to children Skull fracture is only a proxy outcome for intracranial problems |
Hugenholtz H, et al, 1987, Canada | 96 children (GCS 13-15) < 16 yrs 29 children (GCS 8-12) < 16 yrs | Prospective consecutive case series retrospective study of case notes over the previous 2 years | Presence of skull fracture with GCS>12 | No difference | Small sample size Skull fracture is only a proxy outcome for intracranial problems |
Presence of skull fracture GCS 8-12 | Less common in vomiting children | ||||
Chan KH, et al, 1989, Hong Kong | 12072 paediatric head injury cases <16 years. Development of intracranial complications manifested during the first 48 hours of injury | Retrospective case note review | Probability of IC complication with impaired conciousness + skull fracture + | 62% if vomiting vs 74% if not vomiting | Retrospective audit Identification of risk factors is dependant on accurate documentation (which is unlikely) |
Probability of IC complication with normal consciousness + no skull fracture + | 0.08% if vomiting vs 0.14% if vomiting | ||||
Probability of IC complication with impaired conciousness + no skull fracture + | 12% if vomiting vs 18% if no vomiting | ||||
Probability of IC complication with no impaired conciousness + skull fracture + | 1% if vomiting vs 2% if no vomiting | ||||
Ando S, et al, 1992, Japan | 147 patients with head injury, all ages, analysed by age group | Prospective cohort study | Presence of skull fracture | No difference between children vomiting and not vomiting | Small study Results not specific to paediatric patients |
Presence of IC haematoma on CT | No difference between children vomiting and not vomiting | ||||
Dietrich AM, et al, 1993, USA | 324 consecutive trauma patients in an urban childrens hospital requiring CT scanning Mean age 7.1 years | Prospective cohort study | Risk of IC haematoma age <2 | 76/191 patients with no IC lesion had vomited. 10/36 patients with IC lesion had vomited | Small cohort, low event rate |
Risk of IC haematoma age >2 | 12/39 patients with no IC lesion had vomited. 0/3 patients with IC lesion had vomited | ||||
Duus BR, 1993, Denmark | 1876 patients mean age 27.5 (19.9 yrs) | Retrospective case note review | Presence of IC complication | 1.2% if vomiting vs 0.2% if not vomiting | Intracranial complication not defined Retrospective All age groups |
Schunk JE, et al, 1996, USA | 508 patients aged <18 undergoing CT scan for head trauma. 179 excluded for decreased GCS,depressed skull #, bleeding diathesis or develpmental delay. | Retropsective case note review | Abnormal CT findings | 5.5% if vomiting vs 3.4% if not vomiting | No protocol for CT request, inclusion based on physician request Referral bias (major trauma centre) |
Arienta C, et al, 1997, Italy | 10,000 patients with head injury aged between 6 and 95 years (median age 31 years) | Prospective cohort study | Abnormal CT result | 4 of 213 patients with single episode of vomiting had abnormal CT result. 6 of 14 patients with repeated vomiting had an abnormal CT result | Not specific to the paediatric population Low event rate |
Hsiang JN, et al, 1997, Hong Kong | 1360 patients with mild head injury older than 11 years of age | Prospective cohort study | Radiographic abnormailty in GCS 13 group | 4 patients with vomiting vs 11 patients with no vomiting (p=1) | Not specific to paediatric population |
Radiographic abnormality in GCS 14 group | 8 patients with vomiting vs 16 patients with no vomiting (p=0.68) | ||||
Radiographic abnormailty in GCS 15 group | 30 patients with vomiting vs 93 with no vomiting (p=0.924) | ||||
Miller EC, et al, 1997, USA | 2143 patients of all ages with a history of head injury within 2 hours of arrival at the emergency department | Prospective cohort study | Abnormal CT scan | 15% if vomiting vs 5% if not (p<0.001). 20% if nauseous vs 9% if not (p<0.001) | Not specific to paediatric population |
Quayle KS, et al, 1997, USA | 322 consecutive paediatric patients with head injury. All patients had xray and CT | Prospective cohort study | Odds ratio for vomiting predicting intracranial injury | 1.51 (95% CI=0.67 – 3.37) | Non trivial injuries excluded Resultant event rate for IC injury is therefore increased Not all patients had the gold standard investigations |
Postive predictive value for vomiting predicting intracranial injury | 10.9% | ||||
Negative predictive value for vomiting predicting intracranial injury | 92.5% | ||||
Nee P, et al, 1999, UK | 5416 consecutive patients with head injury, over one year period | Prospective cohort study | Incidence of vomiting in children | 12% | Skull fracture is only a proxy outcome for intracranial problems Methods suggest that additional follow up data was collected, but it is not reported |
Sensitivity of detecting skull fracture if child and vomiting | 33.3% | ||||
Specificity of detecting skull fracture if child and vomiting | 93.3% | ||||
Likelihood ratio for child and vomiting (our calc) | 4.9 | ||||
Brown FD, et al, 2000, UK | 563 patients aged 0-13 with minor head injury presenting to a paediatric A+E | Prospective cohort study | Incidence of vomiting | 15.8% | Only minor head injury patients included Not all patients were x-rayed or scanned Very few patients with significant intracranial pathology |
Incidence of skull fracture | <1% | ||||
Incidence of skull fracture + vomiting | 0% |