Alteplase dose in cardiac arrest due to pulmonary embolus

Date First Published:

October 18, 2020

Last Updated:

November 2, 2020

Report by:

Dr. Meghan Ryall, ED SMO (Whakatane Hospital, New Zealand)

Three-Part Question:

[In patients with cardiac arrest from PE] does [a 50 mg IV bolus of Alteplase compared to 100mg given IV over 2 hours] improve [survival rates to ROSC or hospital discharge (any neurologic outcome) without increased risk of stroke/bleeding?]