Topic Tranexamic acid in post circumcision bleeding
Date First Published:
May 13, 2019
Last Updated:
February 1, 2021
Report by:
Alannah Madden , Clinical Fellow (MRI)
Search checked by:
Peter Hulme, MRI
Three-Part Question:
In [patients with post-circumcion bleeding] does [topical tranexamic acid] [reduce bleeding]
Clinical Scenario:
A 4 year old boy attended the paediatric emergency department following a circumcision for religious reasons earlier that day. He had ongoing bleeding from the surgical site.
Is there any evidence behind the use of topical TXA in the management of these patients.
Is there any evidence behind the use of topical TXA in the management of these patients.
Search Strategy:
Using databases : CINAHL, EMBASE, Medline - last 10 years.
(topical tranexamic acid OR TXA).ti,ab
(post circumcision*
bleed*).ti,ab
(topical tranexamic acid OR TXA).ti,ab
(post circumcision*
bleed*).ti,ab
Search Details:
1tCINAHLt(topical tranexamic acid OR TXA).ti,abt614
2tCINAHLt"TRANEXAMIC ACID"/t937
3tCINAHLt(tranexamic acid).ti,abt1547
4tCINAHLt(1 OR 2 OR 3)t1741
5tCINAHLt(post circumcision* bleed*).ti,abt10
6tCINAHLtCIRCUMCISION/t1847
7tCINAHLt(CIRCUMCIS*).ti,abt1977
8tCINAHLt(5 OR 6 OR 7)t2431
9tCINAHLt(4 AND 8)t0
10tEMBASEt(topical tranexamic acid OR TXA).ti,abt1942
11tEMBASEt"TRANEXAMIC ACID"/t12744
12tEMBASEt(10 OR 11)t13151
13tEMBASEt(post circumcision* bleed*).ti,abt35
14tEMBASEtCIRCUMCISION/t8644
15tEMBASEt(CIRCUMCIS*).ti,abt8083
16tEMBASEt(13 OR 14 OR 15)t10281
17tEMBASEt(12 AND 16)t52
18tEMBASEt17 [DT 2009-2020]t42
19tMedlinet(topical tranexamic acid OR TXA).ti,abt2002
20tMedlinet"TRANEXAMIC ACID"/t3331
21tMedlinet(tranexamic acid).ti,abt4189
22tMedlinet(19 OR 20 OR 21)t5717
23tMedlinet(post circumcision* bleed*).ti,abt47
24tMedlinet"CIRCUMCISION, FEMALE"/t1304
25tMedlinet"CIRCUMCISION, MALE"/t5079
26tMedlinet(CIRCUMCIS*).ti,abt6369
27tMedlinet(23 OR 24 OR 25 OR 26)t8388
28tMedlinet(22 AND 27)t6
2tCINAHLt"TRANEXAMIC ACID"/t937
3tCINAHLt(tranexamic acid).ti,abt1547
4tCINAHLt(1 OR 2 OR 3)t1741
5tCINAHLt(post circumcision* bleed*).ti,abt10
6tCINAHLtCIRCUMCISION/t1847
7tCINAHLt(CIRCUMCIS*).ti,abt1977
8tCINAHLt(5 OR 6 OR 7)t2431
9tCINAHLt(4 AND 8)t0
10tEMBASEt(topical tranexamic acid OR TXA).ti,abt1942
11tEMBASEt"TRANEXAMIC ACID"/t12744
12tEMBASEt(10 OR 11)t13151
13tEMBASEt(post circumcision* bleed*).ti,abt35
14tEMBASEtCIRCUMCISION/t8644
15tEMBASEt(CIRCUMCIS*).ti,abt8083
16tEMBASEt(13 OR 14 OR 15)t10281
17tEMBASEt(12 AND 16)t52
18tEMBASEt17 [DT 2009-2020]t42
19tMedlinet(topical tranexamic acid OR TXA).ti,abt2002
20tMedlinet"TRANEXAMIC ACID"/t3331
21tMedlinet(tranexamic acid).ti,abt4189
22tMedlinet(19 OR 20 OR 21)t5717
23tMedlinet(post circumcision* bleed*).ti,abt47
24tMedlinet"CIRCUMCISION, FEMALE"/t1304
25tMedlinet"CIRCUMCISION, MALE"/t5079
26tMedlinet(CIRCUMCIS*).ti,abt6369
27tMedlinet(23 OR 24 OR 25 OR 26)t8388
28tMedlinet(22 AND 27)t6
Outcome:
No evidence for the use of topical tranexamic acid in bleeding post circumcision
Author Commentary:
There is no conclusive evidence published about the use of topical tranexamic acid in bleeding post circumcision.
Bottom Line:
There is nothing published to date about the use of topical TXA in post circumcision bleeds, therefore it is not possible to conclude whether it is effective.