Are patients who have used chewing gum at an increased risk of aspiration during sedation?

A 37 year old male presents with an anterior shoulder dislocation following a rugby match. He states he has not ingested solids for 6 hours or fluids for 2 hours. As you are consenting him for procedural sedation you notice he is chewing gum. Should this patient be regarded as fasted or should an alternate method of facilitating reduction be used due to an increased risk of aspiration?

Does daily prednisolone during a viral infection reduce the risk of relapse in children with steroid dependent nephrotic syndrome?

You see a 6 year old boy in clinic with nephrotic syndrome who is on low dose alternate day prednisolone. He has coryzal symptoms but is otherwise well, with 1+ proteinuria and no oedema. You know that he has previously relapsed following a viral infection and you wonder what you can do to prevent a further relapse. You ask the consultant who suggests increasing his prednisolone dose to daily and you wonder what the evidence is for that.

Hydrotherapy for patients with Multiple Sclerosis

A 61 year old female with MS is about to start a programme of rehab. She has pain in her right hip, stiffness throughout her right lower limb. She finds it difficult to mobilise independently and to climb stairs. Should the rehab programme be land based in rehab gym or a course of hydrotherapy?

Should children with Crohn’s disease start thiopurine treatment at diagnosis?

A 13-year-old boy presents with an 8 month history of abdominal pain, diarrhoea and some weight loss. Investigations confirm Crohn’s disease (CD) of moderate severity. To induce remission you consider either a 6-12 week course of corticosteroids or exclusive enteral nutrition with a polymeric formula for 6 weeks. You plan to reserve the thiopurines (azathioprine [AZA] or 6-mercaptopurine [6-MP]) for second-line therapy. After an internet search, the parents are aware that relapse occurs frequently after initial treatment and that the disease often progresses. They are keen for their son to start a thiopurine straight away.

Evidence supporting Video Assisted Thoracoscopic Surgery as the standard of care in the sub-acute management of the haemodynamically stable chest trauma patient: a review

The trauma team including the cardiothoracic surgical department discusses at a grand round meeting the introduction of a new “adult thoracic trauma” management protocol after patients with thoracic trauma have been stabilised in the emergency department. This protocol involves the use of Video-Assisted Thoracoscopic Surgery (VATS). You are not sure whether VATS is a safe and effective technique for managing thoracic trauma so you decide to look up the evidence yourself.

Combination progesterone and vitamin. D therapy for post traumatic brain injury

You are the emergency department consultant who attends an adult who has been brought in by HEMS following a high speed RTC. He suffered loss of consciousness and was intubated at scene with a GCS 6. He has a sustained a severe closed head injury. You consider if there is any benefit for this patient in receiving combination progesterone and vitamin. D therapy for potential neuroprotection post- traumatic brain injury. Would this therapy improve clinical outcomes for the patient? You resolve to search the literature.

What is the best treatment for acute idiopathic thrombocytopenic purpura in children?

A ten year old girl is admitted with a widespread petechial rash and bleeding gums. A full blood count demonstrates a platelet count of 3,000/mm3 and a diagnosis of idiopathic thrombocytopenic purpura is made. You decide that she warrants medical treatment but have seen both steroids and intravenous immunoglobulins used previously by colleagues. You wonder which treatment is most effective.

Ultrasound guided fascia iliac block in the hands of ED physicians.

A 69yrs female comes after a fall with right hip pain; x rays confirm the diagnosis of fracture neck of femur (NOF). She is very hard to cannulate and you have read an article about anaesthetists putting ultrasound guided fascia iliaca block for NOF fractures. We want to know how good it is in the hands of ED physicians.

Paediatric deaths associated with over the counter cough and cold medicines

A 1-year-old child presents to the emergency department in cardiac arrest. His mother does not speak English; through an interpreter, you learn she gave an unknown cold medication, but she is not sure if she gave the correct amount because she did not understand the English instructions. You wonder whether the cause of the cardiac arrest is more likely to be the underlying condition or over the counter medication.

PE rule-out criteria (PERC) for excluding pulmonary embolism.

A 25-year-old man presents to the ED complaining of pleuritic chest pain and shortness of breath. He is afebrile, has no other symptoms, takes no medications and has never had any surgery. You wonder whether a clinical decision rule such as the (PERC could help exclude PE without the need for D-dimer testing.

Leeches (hirudotherapy) or steroids for traumatic obstructive tongue swelling?

A 49 year old man with known alcoholic liver disease attended the ED, unwell. While in the ED he had a fit and bit his tongue. He only had a platelet count of 28 and so developed massive tongue swelling, which obstructed his airway. He had an emergency tracheostomy and has been sedated and ventilated. He will be transferred to ICU. The ENT surgeon asks for dexamethasone to be started to reduce tongue swelling. As the tongue swelling is caused by a large haematoma you wonder whether he would benfit more from the application of leeches (hirudotherapy)?