Does caffeine treatment for apnoea of prematurity improve neurodevelopmental outcome in later life? n

A 29-week gestation neonate is having frequent apnoeas while on continuous positive airway pressure, so you prescribe caffeine to help prevent apnoeas of prematurity. You notice another baby of the same gestation is not on caffeine but recall reading caffeine treatment may reduce future neurodevelopmental disability. You wonder how strong the evidence is and whether all neonates under 32 weeks gestation should be on caffeine treatment.

Intranasal versus injectable naloxone for opioid overdose

A young man is brought into your emergency department by ambulance with a suspected opiate overdose. His respiratory rate was initially adequate but has now dropped to 7/min, and his GCS is 6. His peripheral veins all seem obliterated and, recognising him from previous attendances, you remember him to be HCV positive. You have heard that naloxone is now given intranasally by a number of ambulance services in the US and wonder whether this might be worth trying.

Do foot pumps improve time to surgery for patients with unstable ankle fractures?

A 25 year old man presents to the emergency department after inversion injury to his ankle. He has sustained an unstable closed ankle fracture, which requires open reduction and internal fixation. An orthopaedic consultant has told you previously that the patient should have a pneumatic foot pump incorporated into the cast, as this will speed the patient''s time to surgery by facilitating the resolution of traumatic oedema. You wonder what the evidence there is to support this.

Should venous sample be used instead of capillary sample for estimation of blood glucose in patients with shock

You are the senior house officer on duty in the emergency department and a 79 year old male is brought in by his son who states that the patient collapsed at home after having sudden onset central abdominal pain radiating through to the back. He is cold and clammy with a pulse rate of 126/ min and his blood pressure reading is 74/46 mm Hg. You commence active resuscitation and the nurse provides you with a blood glucose reading of 1.2 mmol/l. The test was done with a glucometer on a capillary finger prick sample. You commence IV glucose after sending a venous lab sample. The lab result comes back as 23 mmol/l. You dont understand the reason for the difference between the lab result and the glucometer reading. Meanwhile your consultant has also arrived and she says that she has read somewhere in one of the journals that in cases of impaired peripheral perfusion, the glucometer result on a venous sample is more accurate than the capillary sample for assessment of blood glucose. You decide to do a literature search to find the evidence.

Should I use 2.5mg or 5mg Nebulised Salbutamol in Acute Exacerbations of COPD?

While working a busy nightshift in A&E, you see a patient with an acute exacerbation of COPD. They require bronchodilators & the nurse asks you if you want 2.5mg or 5mg of nebulised salbutamol. You usually administer 5mg however wondered if 2.5mg salbutamol would have the same effect?

Response to Nitroglycerin Does Not Predict Cardiac Chest Pain

A 47 year old man arrives to the emergency department with severe chest pain. His chest pain significantly improves with sublingual nitroglycerin. You wonder if the relief of patient’s chest pain with nitroglycerin has any prognostic value in the diagnosis of cardiac chest pain.

Kocher’s or FARES method for reduction of anterior shoulder dislocations

A 36 year-old man presents to the Emergency Department with a painful, deformed left shoulder after falling from his bike on the way to work. Your clinical examination is suggestive of an anterior shoulder dislocation and shoulder X-rays confirm your suspicions. There is no associated fracture or neurovascular deficit. You are aware that there has been much debate about the best method of reduction of anterior shoulder dislocations and have recently been taught how to perform the FARES method. You wonder whether this method or the more traditional Kocher’s method would be the most effective and least painful.

Aspirin in Migraine

A 26 year old male presents to the ED with an acute onset severe unilateral frontal headache and photophobia, similar to previous attacks of migraine but unresponsive to paracetamol, ibuprofen and codeine. You have heard anecdotally that aspirin is effective for migraine and decide to consult the available evidence.

Transected Palmaris Longus Tendon: To repair or not to repair?

A 35 year old right hand dominant carpenter presented to the emergency department after sustaining an injury with his saw to his right wrist. On examination, there was a transverse incision across the palmar crease with an completely transacted Palmaris longus tendon. He had limited range of motion in his wrist due to the swelling. X-ray revealed no fractures or foreign bodies. You wonder if it should be repaired or treated conservatively to give best clinical outcome.